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KMID : 1004820120130010065
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Journal of Biomedical Research
2012 Volume.13 No. 1 p.65 ~ p.70
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Evaluation for the Safety of Bee Venom in ICR Mice
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Cha Chun-Nam
Lee Yeo-Eun
Kang In-Jin
Kim Suk
Lee Hu-Jang
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Abstract
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This study was conducted in order to examine the safety of bee venom as an alternative for antibiotics using male ICR mice. Five-week-old male mice received a single intravenous injection of a dried honey bee venom at the concentration of 0.25 mg/kg (a clinical dose) or 0.5 mg/kg through the tail vein and various pathophysiological analyses were performed after three days. No significant differences in changes of body weight were observed between the saline-treated control group and the experimental groups. In the hematological analysis, none of the parameters were affected by bee venom. In blood biochemistry analysis, none of the markers were affected by administration of bee venom. Similarly, there were no significant effects on markers for liver, kidney, and skeletal muscle functions in all treated- groups. On macroscopic examination, no remarkable lesions were detected in these organs. Because there were no adverse effects of the bee venom in a single intravenous toxicity test for three days, it was concluded that bee venom could be a candidate for a safe natural antibiotic for use in the animal production industry.
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KEYWORD
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Bee venom, Intravenous injection, ICR mouse
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